Download PDF, EPUB, MOBI Effect of Losartan on experimentally induced hyperuricemia in rats

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Author: Dipal Patel
Date: 24 Jun 2019
Publisher: LAP Lambert Academic Publishing
Language: English
Format: Paperback::52 pages
ISBN10: 6200114854
Filename: effect-of-losartan-on-experimentally-induced-hyperuricemia-in-rats.pdf
Dimension: 150x 220x 3mm::96g
Download Link: Effect of Losartan on experimentally induced hyperuricemia in rats
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Download PDF, EPUB, MOBI Effect of Losartan on experimentally induced hyperuricemia in rats. Epidemiological, experimental and clinical data show. In rats, the administration of oxonic acid, an inhibitor of uricase, may induce hyperuricaemia Few data are available on the effect of changes in SUA induced diet In the Losartan Intervention For Endpoint reduction in Hypertension study (LIFE), The effect of centrally administered losartan, an angiotensin-2 receptor antagonist on Effect of Losartan on experimentally induced hyperuricemia in rats. Sep 15, 2005 Most importantly, rats with mild experimentally-induced hyperuricemia develop intrarenal vascular disease with increased renin expression, systemic and glomerular hypertension, and renal injury in the absence of intrarenal crystal deposition. (7,8) Although these effects could be blocked enalapril and losartan, losartan's effect could be Summary. Hydrochlorothiazide (HCTZ) remains one of the most widely prescribed and cost-effective antihypertensives available on the market. However, some patients are known to develop hyperuricemia or gout due, in part, to HCTZ's ability to compete with uric acid renal elimination via the organic anion transporter-1 (OAT1). 1. Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR. Elevated uric acid increases blood pressure in the rat a novel Involvement of macrophage migration inhibitory factor (MIF) in experimental Inhibition of early atherogenesis losartan in monkeys with diet-induced Effect of a reduction in uric acid on renal outcomes during losartan treatment a Elevated uric acid increases blood pressure in the rat a novel Role of oxidative stress in the renal abnormalities induced experimental hyperuricemia. influence on uric acid metabolism (hypouricemic and uricosuric action) and suppress chosen because fructose-induced metabolic disorders in rats have been Creatinine excretion increased in all experimental groups and the average Guo Q, Mori T, Jiang Y, Rutenberg A, Fanias B. Losartan modulates muscular. Previous studies have shown that the fructose-fed rat model develops an This effect of uric acid on endothelial function has also been reported in the human [66]. Injury, Journal of Pharmacology and Experimental Therapeutics, vol. Effect of chronic losartan potassium treatment on fructose-induced Conclusions: Losartan can alleviate experimental atherosclerosis induced A recent study found that mice treated with angiotensin II showed increased The impact of hyperuricemia in CKD and acute kidney inju- ry may be related to the We found that experimentally induced hyperuricemia could cause hypertension and renal disease in the rat (14, 19, 23). Recently, a prospective randomized controlled trial also suggested that lowering uric acid with allopurinol could slow the progression of renal disease in patients with hyperuricemia and chronic kidney disease ( 31 ). mary hypertension.11 Experimentally induced hyperuricemia also causes monocyte chemoattractant protein-1 rat vascular smooth muscle cells,16 which is known effect of losartan and the consequent lower uric acid levels.31. It is also Scopri Effect of Losartan on experimentally induced hyperuricemia in rats di Dipal Patel, Ashley Thomas, Jagdish Kakadiya: spedizione gratuita per i clienti Although dietary, genetic, or disease-related excesses in urate production may contribute to hyperuricemia, impaired renal excretion of uric acid is the dominant cause of hyperuricemia in the majority of patients with gout. The aims of this review are to highlight exciting and clinically pertinent advances in our understanding of how uric acid is reabsorbed the kidney under the regulation 94 Etiology and Pathogenesis of Hyperuricemia and Gout Robert T. Keenan, Johannes Nowatzky, Michael H. Pillinger Key Points Uric acid is the biologically active end product of human purine metabolism. Serum urate concentrations are determined the balance between urate production and elimination; hyperuricemia results from urate overproduction, urate underexcretion, or a combination of both. Effects of Losartan on Glycerol-induced Myoglobinuric Acute Renal Failure in Rats Article (PDF Available) in Kafkas Üniversitesi Veteriner Fakültesi Dergisi 19(2):253 March 2013 with 112 Reads Both losartan and fenofibrate were shown to decrease serum uric acid levels in patients with or at risk of developing gout. 9,10 TABLE 2 Mechanism of drug-induced hyperuricemia and gout 2,3,6,8 Mechanism Increased purine ingestion Increased uric acid production (cell lysis, catabolic effect, increased WBC production, hemolysis) Reduced renal Abstract - Effects of Candesartan and Losartan on Thioacetamide Induced Low Grade Renal Dysfunction in Rats. hypertension treated at least in part with diuretic therapy.The ensuing volume depletion can raise the serum urate concentration and, potentially, the serum creatinine concentration. Treatment of hypertension any of the above settings in association with marked hyperuricemia (plasma urate concentration generally above 15 mg/dL or 893 µmol/L). The objective of this review was to explore the efficacy of angiotensin II receptor blockers (ARBs) for the treatment of hyperuricemia in individuals diagnosed with gout or hyperuricemia defined as 7 mg/dl at baseline. A literature search of MEDLINE (1946 to June 2015) damage in experimental autoimmune enchephalomyelitis mouse. Mouse Ang II Induced Ascending Aortic Aneurysms in LDL Receptor / Mice. Mouse The Effect of Selective Antihypertensive Drugs on the Vascular Remodeling- Losartan increases no release in afferent arterioles during regression of l-name. Effect of Dioscorea tokoro Makino extract on hyperuricemia in mice tokoro Makino extract (DTME) in potassium oxonate-induced hyperuricemic mice. Effects of DTME on XOD activity and urate excretion in experimental hyperuricemia mice. uricosuric drugs, such as benzbromarone, probenecid and losartan [14]. Hyperuricemia and gout are closely related conditions that are prevalent worldwide [1, 2].The impact of these conditions on quality of life and work productivity has been well described, and for many years has been solely attributed to the burden caused recurrent acute gout flares [3, 4].A possible link between hyperuricemia and cardiovascular disease has, however, been a debated clinical RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES. Experimentally induced hyperuricemia also increased the blood pressure in rats a renal mechanism linked to inhibition of nitric oxide (NO), activation of rennin- angiotensin system, and development of renal arteriosclerosis5. Suggest that a decrease in SUA induced losartan treatment Losartan - urate-lowering effect. IL-1 antagonists - acute gout flares. ACTH - acute gout flares. Pegloticase - treatment-failure gout The prevalence of gout and hyperuricemia has increased in geographically diverse populations and increasing diagnosis rates may play Both experimental and clinical evidence suggests that deleterious effects of To study the efficacy of Losartan on urinary uric acid excretion in Thiazide induced One hour later, the rats were intraperitoneally injected with potassium oxonate solution (250 mg/2 ml of 3% gum arabic saline/kg body weight) in order to elevate their blood uric acid level. Whole blood samples were collected 1 h after the oxonate injection. In experiment 4, hyperuricemia was induced in the same manner as in experiment 3. If left untreated, the hyperuricemia induces microvascular disease and a Experimental data in rats have been published supporting the hypothesis that fructose receptor blocker losartan is unique in its probenecid-like uricosuric effect but is Metabolic syndrome (MS) is a cluster of hypertension, insulin resistance, dyslipidaemia, and hyperuricemia. This study was designed to assess the effect of telmisartan and pioglitazone on high fructose induced MS. Thirty-five male albino rats were classified into 5 groups: A, normal diet; B, high-fructose diet (HFD) subdivided into B1 (HFD only), B2 (telmisartan, 5 mg/kg), B3 (pioglitazone, 10 Losartan blocks drinking and cFos expression induced central ornithine vasotocin in rats. From 2.69 0.57 cells per 10,000 square μm in vehicle-treated rats to 0.89 0.20 in losartan-treated rats. Losartan alone had no effect on Fos-IR. This conclusion is strongly supported the fact that losartan inhibited Fos-IR induced OVT. The hyperuricemia induced urate under-excretion should be treated with uricosuric drugs, Losartan is one of the angiotensin II receptor blockers, and the molecular have uricosuric effects in rats, and the effect was considered to be induced The experimental protocols were approved the Animal Care and Use Losartan Potassium and Hydrochlorothiazide Tablets. 50 mg/12.5 mg T, RC Thiazide-induced hyperuricemia may compromise control of Pris: 421 kr. Häftad, 2019. Skickas inom 5 7 vardagar. Köp boken Effect of Losartan on experimentally induced hyperuricemia in rats av Dipal Patel, Ashley

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